Tick Salivary Extract Induces Alpha-Gal Allergy in Alpha-Gal Deficient Mice
نویسندگان
چکیده
منابع مشابه
Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopes.
A major problem with pig-to-human-tissue xenograft studies is that humans have natural antibodies to pig cells; these antibodies would cause hyperacute rejection if pig tissues were xenografted to humans. Here we show that most of human IgM antibodies present in the serum of healthy donors and reactive with pig cells react with galactose in an (alpha 1-3) linkage with galactose--i.e., Gal(alpha...
متن کاملConversion of tumors into autologous vaccines by intratumoral injection of alpha-Gal glycolipids that induce anti-Gal/alpha-Gal epitope interaction
Galili, Uri, "Conversion of tumors into autologous vaccines by intratumoral injection of alpha-Gal glycolipids that induce anti-Gal/ alpha-Gal epitope interaction" (2011). Anti-Gal is the most abundant antibody in humans, constituting 1% of immunoglobulins. Anti-Gal binds specifically α-gal epitopes (Galα1-3Galβ1-4GlcNAc-R). Immunogenicity of autologous tumor associated antigens (TAA) is greatl...
متن کاملAcceleration of wound healing by alpha-gal nanoparticles interacting with the natural anti-Gal antibody
This work is licensed under a Creative Commons Attribution 3.0 License. Galili, Uri, "Acceleration of wound healing by alpha-gal nanoparticles interacting with the natural anti-Gal antibody" (2015).
متن کاملAlpha-gal anaphylaxis: the first case report in Italy.
We report the case of a 55-year-old man who went into anaphylactic shock six hours after eating a meal containing meat. He reported having had several tick bites in months before the reaction. The serum specific IgE showed strong positivity to alpha-gal. This is clearly alpha-gal anaphylaxis with delayed onset after meat ingestion caused by tick bite, confirmed by alpha-gal IgE positivity.
متن کاملDelayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat.
IgE-mediated hypersensitivity refers to immune reactions that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. To that end, identification of the associated allergen is important for facilitating both education and allergen avoidance that are essential to long-term risk reduction. As the number of known exposures associated with anaphylaxis is limited, discove...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2019
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2018.12.771